Blog Post
February 24, 2021

TSPG and TLFRCC (thyroid-like follicular renal cell carcinoma)

Eva Comperat's session at the 2021 GUASCO described several new Kidney cancer subtypes including a thyroid-like variant dubbed TLFRCC.  Ko describes this variant in her paper "Whole-genome and transcriptome profiling of a metastatic thyroid-like follicular renal cell carcinoma".  Since my p1RCC might be related to thyroid cancer, I decided to investigate.  I created two tables by

Based on the tables below, I suspect that my cancer is not of this variant.

Abstract

  Gene BP-Tumor TCGA-BQ-5884 TCGA-BQ-7051 TCGA-DZ-6131 TCGA-GL-7966 TCGA-Y8-A8RY
871 AR -0.211614 -0.017011 -0.364995 -0.123798 -0.121868 -0.231878
9983 MYC -0.106763 -0.061247 -0.102986 -0.262828 -0.315389 0.021576
9137 MAP2K2 -0.054956 -0.015010 0.050954 -0.182945 -0.047145 -0.104429
2933 CDK6 -0.051317 -0.021210 -0.123691 -0.074179 -0.078184 -0.044222
11452 PDGFRB 0.238150 0.167966 0.319553 0.036347 0.027004 0.242385
11451 PDGFRA 0.367115 0.315557 0.380796 0.229878 0.234411 0.358568

 

Table1

  Gene BP-Tumor TCGA-BQ-5884 TCGA-BQ-7051 TCGA-DZ-6131 TCGA-GL-7966 TCGA-Y8-A8RY
4710 E2F1 -0.268096 -0.210663 -0.312030 -0.380435 -0.442005 -0.215067
4711 E2F2 -0.266385 -0.258009 -0.400997 -0.443134 -0.571322 -0.224849
2690 CCNA2 -0.228158 -0.201702 -0.313020 -0.347024 -0.591778 -0.227453
9323 MDM4 -0.209965 -0.095992 -0.143609 -0.031123 -0.286186 -0.142436
16373 TOP2A -0.205414 -0.211388 -0.262869 -0.294304 -0.538290 -0.194491
9983 MYC -0.106763 -0.061247 -0.102986 -0.262828 -0.315389 0.021576
16390 TP53 -0.100091 -0.071941 -0.260981 -0.117477 -0.383892 -0.103676
12815 RAD51 -0.092361 -0.119231 -0.211125 -0.210738 -0.433904 -0.143697
4712 E2F3 -0.073424 -0.138427 -0.197478 -0.131264 -0.292214 -0.016827
9137 MAP2K2 -0.054956 -0.015010 0.050954 -0.182945 -0.047145 -0.104429
2933 CDK6 -0.051317 -0.021210 -0.123691 -0.074179 -0.078184 -0.044222
3503 COL1A1 -0.016258 -0.044517 -0.010810 -0.159825 -0.277542 0.010240
2774 CD274 -0.003547 -0.247358 0.062292 -0.167837 -0.096958 0.074009
5781 FHIT 0.009491 -0.020224 0.003310 0.062299 0.178956 -0.003514
1576 BRD4 0.025710 -0.005122 0.033947 -0.066529 -0.162211 0.042427
5083 ERBB2 0.026003 0.170631 0.005395 0.187722 0.178390 0.010045
12447 PRSS8 0.033081 0.105601 0.064322 0.122759 0.594064 0.041250
12554 PTEN 0.125224 -0.081410 0.075240 -0.038048 -0.064603 0.100576
3856 CTNNB1 0.128816 0.019109 -0.035645 0.121470 0.147212 0.220156
11452 PDGFRB 0.238150 0.167966 0.319553 0.036347 0.027004 0.242385
11451 PDGFRA 0.367115 0.315557 0.380796 0.229878 0.234411 0.358568
8759 LMO1 0.421346 0.370964 0.425843 0.262508 -0.028689 0.436359

 

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