Dr. Rachel Giles’ lab focuses on understanding how the cilium regulates renal epithelial proliferation. We interrogate ciliary regulation of the cell cycle and cell signaling through these proteins using in vitro renal cell culture and proteomics, ex vivo kidney explant culture, and in vivo zebrafish models. Recently, we have invested in an integrated systems biology approach to understand the cilium in proliferative states such as kidney cancer, tissue regeneration and nephronophthisis/polycystic kidney diseases.