Blog Post
May 24, 2018

2018 Kidney Cancer Hackathon Results: Bill's p1RCC Genes

This cross references Alex Feltus and James Hsieh's work with Genes of interest from the Teams. GNOME overlaps with two teams.  Otherwise, everyone found something different.  Readers can see how these genes were selected by looking at the code from the teams post. All lists using data from TCGA.








Team

CLASS

ENSGeneID

GeneSymbol

GeneDescription

GeneSymbolID

Other Refs

/somatic/results/variants/snpEff_genes.txt

Aizheng

KINC-KIRP_EDGE

ENSG00000023902

PLEKHO1

pleckstrin homology domain containing O1

https://www.genecards.org/cgi-bin/carddisp.pl?gene=PLEKHO1

   

Aizheng

KINC-KIRP_EDGE

ENSG00000110852

CLEC2B

C-type lectin domain family 2 member B

https://www.genecards.org/cgi-bin/carddisp.pl?gene=CLEC2B

 

Aizheng

KINC-KIRP_EDGE

ENSG00000129824

RPS4Y1

ribosomal protein S4, Y-linked 1

https://www.genecards.org/cgi-bin/carddisp.pl?gene=RPS4Y1

UNC HiSeq mRNAseq gene expression.ipynb

 

Aizheng

KINC-KIRP_EDGE

ENSG00000171903

CYP4F11

cytochrome P450 family 4 subfamily F member 11

https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP4F11

 

Aizheng

KINC-KIRP_EDGE

ENSG00000198074

AKR1B10

aldo-keto reductase family 1 member B10

https://www.genecards.org/cgi-bin/carddisp.pl?gene=AKR1B10

Esmo2015.pdf - AKR1B10, a new prognostic indicator in nasopharyngeal carcinoma

Aizheng

KINC-KIRP_EDGE

ENSG00000241839

PLEKHO2

pleckstrin homology domain containing O2

https://www.genecards.org/cgi-bin/carddisp.pl?gene=PLEKHO2

   

Aizheng

KINC-KIRP_EDGE

ENSG00000230535

BASP1P1

pseudogene

https://www.genecards.org/cgi-bin/carddisp.pl?gene=BASP1P1

 

Aizheng

KINC-KIRP_EDGE

ENSG00000262619

LINC00621

long intergenic non-protein coding RNA 621

https://www.genecards.org/cgi-bin/carddisp.pl?gene=LINC00621

 

HSIEH

HSIEH

ENSG00000147889

CDKN2A

cyclin dependent kinase inhibitor 2A [Source:HGNC Symbol;Acc:HGNC:1787]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=CDKN2A

   

HSIEH

HSIEH

ENSG00000107984

DKK1

dickkopf WNT signaling pathway inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:2891]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=DKK1

   

HSIEH

HSIEH

ENSG00000104332

SFRP1

secreted frizzled related protein 1 [Source:HGNC Symbol;Acc:HGNC:10776]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SFRP1

   

HSIEH

HSIEH

ENSG00000134086

VHL

von Hippel-Lindau tumor suppressor [Source:HGNC Symbol;Acc:HGNC:12687]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=VHL

   

HSIEH

HSIEH

ENSG00000163939

PBRM1

polybromo 1 [Source:HGNC Symbol;Acc:HGNC:30064]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=PBRM1

   

HSIEH

HSIEH

ENSG00000181555

SETD2

SET domain containing 2 [Source:HGNC Symbol;Acc:HGNC:18420]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SETD2

   

HSIEH

HSIEH

ENSG00000126012

KDM5C

lysine demethylase 5C [Source:HGNC Symbol;Acc:HGNC:11114]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=KDM5C

   

HSIEH

HSIEH

ENSG00000163930

BAP1

BRCA1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:950]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=BAP1

   

HSIEH

HSIEH

ENSG00000284792

PTEN

phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=PTEN

   

HSIEH

HSIEH

ENSG00000198793

MTOR

mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=MTOR

   

HSIEH

HSIEH

ENSG00000141510

TP53

tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=TP53

   

HSIEH

HSIEH

ENSG00000121879

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=PIK3CA

   

HSIEH

HSIEH

ENSG00000105976

MET

MET proto-oncogene, receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=MET

   

HSIEH

HSIEH

ENSG00000083857

FAT1

FAT atypical cadherin 1 [Source:HGNC Symbol;Acc:HGNC:3595]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=FAT1

   

HSIEH

HSIEH

ENSG00000186575

NF2

neurofibromin 2 [Source:HGNC Symbol;Acc:HGNC:7773]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=NF2

   

HSIEH

HSIEH

ENSG00000147050

KDM6A

lysine demethylase 6A [Source:HGNC Symbol;Acc:HGNC:12637]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=KDM6A

   

HSIEH

HSIEH

ENSG00000099956

SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 [Source:HGNC Symbol;Acc:HGNC:11103]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SMARCB1

   

HSIEH

HSIEH

ENSG00000116044

NFE2L2

nuclear factor, erythroid 2 like 2 [Source:HGNC Symbol;Acc:HGNC:7782]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=NFE2L2

   

HSIEH

HSIEH

ENSG00000101972

STAG2

stromal antigen 2 [Source:HGNC Symbol;Acc:HGNC:11355]

https://www.genecards.org/cgi-bin/carddisp.pl?gene=STAG2

   

DeeperDrugs

   

TTRAP

**

     

DeeperDrugs

   

CDK9

       

DeeperDrugs

   

BARD1

See GNOME

     

DeeperDrugs

   

APOB

       

BioMarkers.ai

   

FHL1

benzopyrine exposure biomarker

     

BioMarkers.ai

   

KNG1

Widest Discrimination Gap, ssential for blood coagulation

     

BioMarkers.ai

   

UMOD

Early Diagnosis Urine-based Biomarker

     

codeomics

   

ABL1

       

codeomics

   

PIK3CA

       

codeomics

   

mTOR

       

ExpressForce

     

**

     

GNOME

   

BARD1

See DeeperDrugs

     

GNOME

   

AHNAK

       

GNOME

   

RBMX

       

GNOME

   

ANAPC1

       

GNOME

   

STARD13

       

GNOME

   

DNAJ27

       

GNOME

   

SCYL1

       

GNOME

   

PDE4DIP

See HelloKidney2

     

GNOME

   

BCLAF1

       

GNOME

   

PABPC1

       

HelloKidney

   

TNFSF4

       

HelloKidney

   

ITGAM

       

HelloKidney2

   

PSPN

False Positive

     

HelloKidney2

   

FOLH1

       

HelloKidney2

   

TAS2R19

       

HelloKidney2

   

PDE4DIP

See GNOME

     

HelloKidney2

   

PFKP

       

HIF1AIsNotAnOncogene

   

HER2

       

HIF1AIsNotAnOncogene

   

CDK4

       

HIF1AIsNotAnOncogene

   

E2F2

       

HIF1AIsNotAnOncogene

   

FGFR1

       

HIF1AIsNotAnOncogene

   

MAPK8

       

HIF1AIsNotAnOncogene

   

MSH2

       

HIF1AIsNotAnOncogene

   

PARP1

       

HIF1AIsNotAnOncogene

   

STAT5B

       

KidneyBean

   

TUBB8

       

studentec

 

ENSG00000116337

AMPD2

       

studentec

 

ENSG00000117069

ST6GALNAC5

       

studentec

 

ENSG00000130226

DPP6

       

studentec

 

ENSG00000143520

FLG2

       

studentec

   

FTMT

       
Biology

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